General Affairs Division (formerly known as The Humanities Center) was originally conceived as a university-level center to promote academic exchange among faculty members within the College of Liberal Arts. The proposal for its establishment was approved in principle by the university council at the end of the 2001. In 2004, the university began actively providing funding and preparing for the establishment of a university-level humanities research center. On April 17, 2007, the center was formally approved by the Ministry of Education and positioned as a research institution focused on promoting international/intercollegiate academic activities, talent development and recruitment. It was also the earliest-established humanities research center in Taiwan, reflecting the university's emphasis on and commitment to humanities research.

In August 2009, the center appointed Professor Hung, Wei-Chu to continue the Kunqu Opera Development Project. In April 2014, the "Research Office for Hermeneutics and Cultural Interdisciplinary Philosophy" was established to strengthen international connections. In November 2017, the "Kunqu Opera Museum" was established.

In addition to its basic functions such as lectures and seminars, the center began to focus on campus activities in 2020. On one hand, it collaborates with the College of Liberal Arts to organize cross-departmental events, and on the other hand, it assists in publishing. In addition to administrative work related to the college's journals, the center is also involved in publishing projects that encompass the entire university, such as the school history book "National Central University and the Republic of China" and the compilation of the results of the "Yu Chi-Chung Lecture" for alumni. Furthermore, the center plans to cooperate with other units such as the Library, Gallery of NCU History, Art Center and NCU Press to create a humanistic space, expand its scope of concern, and attempt to break down disciplinary boundaries, promoting dialogue between humanities and scientific research and striving to develop the university into a "world’s top universities with deep humanistic concerns."